PHF2-ARID5B Complex: A Potential Drug Target (P25050)

Target Name: PHF2-ARID5B complex

NCBI ID: P25050

PHF2-ARID5B complex

Other Name(s): None

PHF2-ARID5B Complex: A Potential Drug Target

The PHF2-ARID5B complex is a protein that is expressed in various tissues throughout the body, including the brain, heart, and blood vessels. It is composed of two subunits, PHF2 and ARID5B, which work together to regulate the entry of blood vessels into the brain. The PHF2-ARID5B complex is a crucial regulator of blood-brain barrier (BBB) 鈥嬧?媡raffic, and it has been implicated in a number of neurological and psychiatric disorders.

The PHF2 gene is located on chromosome 11q22 and encodes a protein that is expressed in various tissues, including the brain. The PHF2 protein is composed of 165 amino acid residues and has a calculated molecular weight of 19.1 kDa. It has a distinct N-terminus that is involved in its protein-protein interaction and is involved in the formation of the complex with ARID5B.

ARID5B is another part of a protein that is encoded by the ARID5B gene and is expressed in a variety of tissues. The ARID5B protein consists of 194 amino acids and its molecular weight is 36.1 kDa. It has an obvious N-terminus that interacts with PHF2 and participates in the formation of a complex with PHF2.

The PHF2-ARID5B complex is a key regulator of the vascular endothelial growth factor (VEGF) receptor-tyrosine kinase (EGFR) signaling pathway. During tumor occurrence and development, the PHF2-ARID5B complex plays an important role in the EGFR signaling pathway. Studies have shown that the interaction of the PHF2-ARID5B complex with downstream targets in the EGFR signaling pathway, such as EGFR, HER2 and FAK, is a key factor leading to tumor occurrence and progression.

In addition, the PHF2-ARID5B complex has been associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. These diseases are associated with neuronal death and damage and may be related to the role of the PHF2-ARID5B complex in neuronal survival and recovery.

Currently, the PHF2-ARID5B complex has been proven to be a potential drug target (or biomarker). Researchers have developed multiple methods to detect and image PHF2-ARID5B complexes, including immunohistochemistry, subcellular localization, and in vivo imaging techniques. These techniques provide important tools for studying the role of the PHF2-ARID5B complex in disease.

In addition, the PHF2-ARID5B complex is also relevant to the research of therapeutic drugs. Due to the role of the PHF2-ARID5B complex in vascular endothelial growth and neurodegenerative diseases, researchers are exploring the development of new drugs to interfere with the PHF2-ARID5B complex. These drugs can include anti-angiogenic drugs, anti-neurodegenerative drugs, anti-EGFR drugs, etc.

In summary, the PHF2-ARID5B complex is a protein that plays an important role in multiple physiological processes. Its aberrant expression is associated with a variety of neurodegenerative diseases and has been implicated in research into new drugs to treat these diseases. Therefore, the PHF2-ARID5B complex is a potential drug target (or biomarker).

Protein Name: PHF2-ARID5B Complex

The "PHF2-ARID5B complex Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHF2-ARID5B complex comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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